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. 2022 Oct 11;10(10):e004653. doi: 10.1136/jitc-2022-004653

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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The early colorectal tumorigenic steps require complex immune reactions to develop. (A) Representative dot plot graphs of CD4+ and CD8+ lymphocytes gated for CD45+, live cells, and singlet. (B–D, F, G, J–O) Gene expression analysis for Cd8 (B, n=8, *p=0.02; H, n=13, p>0.05; O, n=9, *p=0.03), Mcpt1 (C, n=8, *p=0.02; G, n=13, *p=0.02; M, n=9, *p=0.01), Mcpt4 (D, n=8, *p=0.02; F, n=13, *p=0.02; N, n=9, *p=0.01), Ctnnb1 (J, n=9, *p=0.03), and Mki67 (L, *p=0.03) in B2MKO, CiitaKO, and St2KO mice, and their counterparts. (E, I, P) Representative images of multiplex IHC staining with anti-CD8, anti-CD3, and anti-TRY antibodies (magnification at 50 µm). Data are shown as the median, highest and lowest values, and upper and lower quartiles. P values were calculated using a two-tailed Mann-Whitney’s U test. IHC, immunohistochemistry.