Table 1.

Eligibility criteria and relevant definitions of the UK-EDI cohort

Criteria/definition	Details
Inclusion criteria	Aged≥50 years at the time of study entry New-onset diabetes (defined at HbA1c≥48 mmol/mol (6.5%) diagnosed within 6 months of study entry Willing to provide written informed consent prior to performing any protocol-related procedures Willing and able to comply with the protocol for the duration of the study, including scheduled follow-up visits
Exclusion criteria	Diagnosis or treatment of pancreatic cancer, peri-pancreatic cancer, or pancreatic endocrine cancer Previous surgical resection of the pancreas Diagnosis of diabetes>6 months prior to study entry Pregnancy Condition preventing study investigation and follow-up Inability or incapacity to give written informed consent
Definition of new-onset diabetes	HbA1c≥48 mmol/mol (6.5%) diagnosed within 6 months of study entry
Identification of PDAC diagnoses	NHS digital will be interrogated to update occurrence of PDAC

HbA1c, glycated haemoglobin; PDAC, pancreatic ductal adenocarcinoma; UK-EDI, UK Early Detection Initiative for Pancreatic Cancer.