Table 2.

Eligibility criteria and relevant definitions of the UK-EDI cohort

Data item	Details
EDTA stored blood	Translational blood samples taken at baseline, 6, 12, 18 and 24 months stored to GCP standards
Serum stored blood	Translational blood samples taken at baseline, 6, 12, 18 and 24 months stored to GCP standards
HbA1c measurements	HbA1c measurements from diagnosis, baseline, 6, 12, 18 and 24 months
Demographics	Details including ethnicity, smoking, and alcohol status
Anthropometric data	Height, weight, waist and hip measurements taken at baseline, 6, 12, 18 and 24 months
Biochemistry and symptomology of diabetes onset	Details regarding symptoms at the time of diabetes diagnosis and prior biochemical (HbA1c) data pre-diagnosis (left-window)
Symptomology relevant to pancreatic cancer	Detailed information regarding symptoms typical of onset of pancreatic cancer, and changes from baseline at 6, 12, 18 and 24 months
DSMQ	The diabetes self-management questionnaire. A validated instrument assessing self-care behaviours associated with diabetes control. Measured at baseline, 6, 12, 18 and 24 months
EQ-5D-5L	Standardised measure of health-related quality of life measured at baseline, 6, 12, 18 and 24 months
Medical and surgical history	Changes to medical and surgical diagnoses at baseline, 6, 12, 18 and 24 months
Medication history	Changes to prescribed medication, including for diabetes, at baseline, 6, 12, 18 and 24 months
Pancreatic malignancy data	Data from subsequent pancreatic cancer diagnoses, including surgical and oncological therapy.

DSMQ, Diabetes Self-Management Questionnaire; EQ-5D-5L, EuroQol Research Foundation Quality of Life Questionnaire; GCP, good clinical practice; HbA1c, glycated haemoglobin.