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. 2022 Oct 7;9(5):ENEURO.0218-22.2022. doi: 10.1523/ENEURO.0218-22.2022

Figure 4.

Figure 4.

Slower RORR (return of righting reflex) and longer LORR duration in Mbnl2 KO mice administered zolpidem. Mbnl2 and WT mice were administered 60 mg/kg of zolpidem (intraperitoneal). A, No propensity for Mbnl2 KO (N = 12) mice to LORR at higher rate compared with WT (N = 11) mice as LORR rate was 100% successful for both genotypes. B, No significant difference in LORR latency between genotypes (t(19.62) = 0.646, p = 0.53, Welch’s t test. C, Mbnl2 KO mice take significantly longer to emerge than WT mice (RORR; t(2.03) = 19.60, p = 0.05, Welch’s t test). D, Mbnl2 KO mice display longer sedation period (LORR duration) compared with WT mice (t(2.133) = 18.24, p = 0.05, Welch’s t test.) No significant difference in LORR metrics between WT and Mbnl2 KO mice administered THIP (Extended Data Fig. 4-1). Error bars are ± SEM. Full statistical analyses provided in Extended Data Figures 4-2 and 4-3.