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. 2022 Sep 29;14:957665. doi: 10.3389/fnagi.2022.957665

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Copyright © 2022 Pautex, Bianchi, Daali, Augsburger, de Saussure, Wampfler, Curtin, Desmeules and Broers.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CYP1A2, CYP2C19, and CYP3A4 enzymatic activities. Box plot representing the CYP1A2, CYP2C19, and CYP3A4 metabolic ratios at 1st and 2nd blood sampling. Geneva cocktail reference values (–SD to + SD): CYP1A2 = PM (poor metabolizer) 0.03–0.204; EM (normal metabolizer) 0.17–0.39; UM (ultra-metabolizer) 0.42–0.70. CYP2C19 = PM (poor metabolizer) 0.08–0.28; EM (normal metabolizer) 0.3–1.22; UM (ultra-metabolizer) 2.96–7.88. CYP3A4 = PM (poor metabolizer) 0.15–0.29; EM (normal metabolizer) 0.32–0.82; UM (ultra-metabolizer) 2.21–5.25. For CYP2C9, CYP2B6, and CYP2D6 graphics in Supplementary Figures B1, B2.