Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Oct 11;14:17590914221131446. doi: 10.1177/17590914221131446

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

PMC Copyright notice

Figure 4. — Systemic ancrod administration reduces retinal fibrinogen accumulation in the diabetic murine retina. (A) Confocal images of retinas from 10-week nondiabetic and diabetic LPS-treated CX3CR1-WT and CX3CR1-KO mice display fibrinogen deposits (white) along CD31⁺ retinal vessels (red), which are not detectable in the ancrod-treated diabetic retina. (B) Quantification of fibrinogen in retinal tissues indicates elevated fibrinogen accumulation in retinas of nondiabetic and diabetic LPS-treated mice relative to naïve and ancrod-treated diabetic mice. n = 4–9 mice per group. Each point represents data from an individual mouse. * P <0.05, ** P <0.01, *** P <0.001, **** P <0.0001. Scale bars: 25 µm.