Figure 5.

Defibrinogenation improves visual acuity in diabetic mice. (A, B) Schematic layout of the visual acuity cues and location of the high-value food reward during each trial in the two-choice discrimination task chamber. (C) Quantification of the percentage of correct first dig location per animal indicates that 10-week diabetic LPS-treated mice in visible light conditions perform in a manner comparable to sighted naïve animals placed in infrared light (non-sighted) conditions. Treatment to reduce fibrinogen systemically using ancrod improves visual acuity in 10-week diabetic animals compared to untreated diabetic animals. n = 5–9 mice per group. Each point represents data from an individual mouse. * P <0.05, ** P <0.01, **** P <0.0001.