Table 2.
Inflammatory Mediator Profile in the Mouse Retina.
| Diabetic | Ancrod | |||
|---|---|---|---|---|
| Mediator | WT | KO | WT | KO |
| IL-1α | 2.922 | 2.114 | 0.856 | 0.515 |
| IL-1β | 3.179 | 3.418 | 0.379 | 0.306 |
| IL-2 | 2.788 | 2.400 | 1.055 | 0.714 |
| IL-3 | 3.565 | 4.564 | 0.042 | 0.008 |
| IL-4 | 2.883 | 4.046 | 0.175 | 0.149 |
| IL-5 | 3.026 | 4.259 | 0.118 | 0.118 |
| IL-6 | 2.930 | 3.816 | 0.272 | 0.202 |
| IL-9 | 2.748 | 3.003 | 0.449 | 0.357 |
| IL-10 | 3.308 | 4.367 | 0.029 | 0.079 |
| IL-12 (p40) | 3.208 | 4.253 | 0.268 | 0.117 |
| IL-12 (p70) | 3.503 | 5.341 | 0.085 | 0.132 |
| IL-13 | 2.919 | 3.244 | 0.374 | 0.346 |
| IL-17A | 3.119 | 3.423 | 0.101 | 0.068 |
| Eotaxin | 3.209 | 3.444 | 0.393 | 0.347 |
| G-CSF | 3.370 | 4.842 | 2.249 | 0.532 |
| GM-CSF | 3.004 | 3.543 | 0.087 | 0.020 |
| IFN-γ | 2.861 | 3.111 | 0.473 | 0.384 |
| KC | 2.797 | 3.621 | 0.572 | 0.295 |
| MCP-1 | 2.875 | 3.245 | 0.379 | 0.191 |
| MIP-1α | 3.025 | 4.192 | 3.154 | 1.120 |
| MIP-1β | 3.259 | 3.604 | 0.113 | 0.054 |
| RANTES | 2.656 | 2.184 | 0.901 | 0.586 |
| TNF-α | 3.394 | 3.799 | 0.262 | 0.389 |
Note. Inflammatory mediator levels in the diabetic and ancrod-treated diabetic mouse retina denoted as fold change values relative to naïve CX3CR1-WT and CX3CR1-KO mice, respectively. All cytokine and chemokine concentrations (obtained in pg per mL) were normalized to the amount of soluble protein per retinal extract sample, yielding the amount of inflammatory mediator within the murine retina in pg of mediator per mg of retinal protein. The respective fold change values, shown in the table, were calculated using the mean normalized inflammatory mediator values from naïve retinas for each genotype. n = 5–8 mice per group.