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. 2022 Sep 29;7(40):35656–35667. doi: 10.1021/acsomega.2c03444

Table 2. CC50, IC50 (μg/mL), and IS of 6c, 6d, and 8c Compounds with Viral Reduction 50% or More.

herpes simplex virus
compd no. mean % of reduction nontoxic dose (μg/mL) CC50 (μg/mL) IC50 (μg/mL) IS
6c 83% 100 1.8 0.55 3.4
6d 80% 100 1.6 0.57 2.8
8c 86% 100 2.0 0.57 3.5
acyclovir 99% - 2.7 0.07 4.00
HCVcc genotype virus
6c 63.3% 100 1.9 0.76 2.5
8c 66.7% 100 1.7 0.71 2.4
coxsackievirus B4
6c 63.3% 100 1.9 0.76 2.5
6d 50.0% 100 1.7 1.0 1.7
8c 66.7% 100 1.7 0.69 2.4