Table 2.
Chitosan-containing liposomes and chitosan-coated liposomes characteristics: mean diameter (≤80%, nm), polydispersity index (PI), zeta potential, entrapment efficacy (EE%), and pH in aqueous medium.
| Size (≤80%, nm) | PI | Zeta potential (mV) | EE% | pH | |
|---|---|---|---|---|---|
| PL | 308 ± 22 | 0.37 ± 0.04 | −1.6 ± 1.4 | – | 5.8 ± 0.5 |
| PL-CHX | 305 ± 14 | 0.38 ± 0.03 | 42.9 ± 5.9 | 63.2 ± 4.8 | 8.5 ± 0.1 |
| CH | 303 ± 18 | 0.32 ± 0.01 | 12.4 ± 0.4 | – | 3.6 ± 0.0 |
| CH-CHX | 300 ± 24 | 0.34 ± 0.07 | 94.9 ± 2.2 | 65.7 ± 4.8 | 3.7 ± 0.0 |
| CO | 325 ± 23 | 0.35 ± 0.01 | 13.0 ± 0.4 | – | 3.7 ± 0.0 |
| CO-CHX | 393 ± 23 | 0.39 ± 0.02 | 83.3 ± 3.1 | 70.4 ± 3.9 | 3.8 ± 0.0 |
Results of size measurements are expressed as means of cumulative size ≤ 80% of vesicle populations (weight-intensity distribution) with their respective SD, while the rest of the results are expressed as means with their respective SD (n = 3). PL, Plain, empty lipid carrier; PL-CHX, Plain CHX-lipid carrier; CH, Chitosan-containing empty liposomes; CH-CHX, Chitosan-containing CHX-liposomes; CO, Chitosan-coated empty liposomes; and CO-CHX, Chitosan-coated CHX-liposomes.