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. 2022 Sep 29;12:975643. doi: 10.3389/fonc.2022.975643

Table 3.

Dose Limiting Toxicities by Dose Level.

Total patients in dose level ObservedDLTs DLT Information
Dose Level 1 (100 mg BID) 3 0
Dose Level 2 (125 mg BID) 20 2

  • Grade 3 Hypertension

  • Grade 3 Abdominal pain
Dose Level 3 (150 mg BID) 5 2

  • Grade 3 Abdominal pain

  • Grade 3 AST elevation
Dose Level 4 (175 mg BID) 1 1

  • Grade 3 AST elevation
All 29 5