Table 1.
Summary of the facts reported in 103 literatures curated in PubMed database for finding the neurological symptoms of COVID-19 selected for the construction of TN.
| Study type | Patients (% Males) |
Timeline | PubMed ID of screened articles | Remarks on COVID-19 patients Period of CNS symptoms identified: Status of Patients |
|---|---|---|---|---|
|
Case study (18) |
4 (75%) | Jan–Apr, 2020 | 32314810, 32474220, 32457227, 32449057 | During ICU hospitalisation: Died after 10–12 days |
| 1 (100%) | 2020 | 32737799 | During hospitalisation with COVID-19: Recovered during release | |
| 1 (100%) | 2020 | 32730234 | During hospitalisation with COVID-19: Recovered during release | |
| 2 (100%) | 2020 | 32600350, 32409316 | During hospitalisation with COVID-19: Recovered during release | |
| 2 (50%) | 2020 | 32615528, 32367205 | During hospitalisation with COVID-19: Recovered during release | |
| 1 (0%) | 2020 | 32545925 | During hospitalisation with COVID-19: Recovered during release | |
| 1 (0%) | 2020 | 32518103 | During hospitalisation with COVID-19: Recovered during release | |
| 1 (0%) | 2020 | 32689590 | During hospitalisation with COVID-19: Recovered during release | |
| 3 (66.7%) | 2020 | 32464585, 32430637, 32418288 | During hospitalisation with COVID-19: Recovered during release | |
| 2 (0%) | 2020 | 32489724, 32586897 | During hospitalisation with COVID-19: Recovered during release | |
|
Case series (6) |
4 (50%) | 2020 | 32679347 | During hospitalisation with COVID-19: 3 patients with CNS problem during release |
| 2 (100%) | Mid-March, 2020 | 32462412 | During hospitalisation with COVID-19: 1 died, 1 with long-term monitoring | |
| 2 (50%) | 2020 | 32464157 | During hospitalisation with COVID-19: Recovered during release | |
| 6 (83.3%) | Mar 16–Apr 5, 2020 | 32436105 | During hospitalisation with COVID-19: 5 died, 1 with severe neurological deficits | |
| 4 (25%) | 2020 | 32360439 | During hospitalisation with COVID-19: 3 died, 1 release | |
| 2 (0%) | 2020 | 32307298 | During hospitalisation with COVID-19: 1 died, 1 release | |
|
Clinical cohort (16) |
140 (71.4%) | May 3–May 5, 2020 | 32771053 | During ICU hospitalisation with COVID-19: Not specified |
| 89 (61.8%) | Mar 23–May 23, 2020 | 32756734 | During ICU hospitalisation with COVID-19: Not specified | |
| 64 (67.2%) | Mar 6–Apr 9, 2020 | 32680942 | During ICU hospitalisation with COVID-19: Not specified | |
| 73 (65.8%) | Mar 23–May 7, 2020 | 32677875 | During hospitalisation with COVID-19: Not specified | |
| 86 (62.8%) | Feb 5–Apr 2, 2020 | 32754114 | During ICU hospitalisation with COVID-19: Not specified | |
| 9 (77.8%) | 2020 | 32639679 | During hospitalisation with COVID-19: Not specified | |
| 43 (55.8%) | Apr 9–May 15, 2020 | 32637987 | During hospitalisation with COVID-19: Not specified | |
| 4 (50.0%) | Mar 1–May 8, 2020 | 32609336 | During hospitalisation with COVID-19: Not specified | |
| 50 (58.0%) | Mar 1–Apr 30, 2020 | 32570113 | During hospitalisation with COVID-19: Not specified | |
| 10 (80.0%) | Mar 1–Apr 15, 2020 | 32466736 | During ICU hospitalisation with COVID-19: Not specified | |
| 163 | Feb–Mar, 2020 | 32467244 | During hospitalisation with COVID-19: Not specified | |
| 242 (62.0%) | Mar 1–Mar 31, 2020 | 32467191 | During hospitalisation with early COVID-19: Not specified | |
| 27 (74.1%) | Mar 1–Apr 14, 2020 | 32439651 | During hospitalisation with COVID-19: Not specified | |
| 454 (60.8%) | Mar 1–Apr 13, 2020 | 32447193 | During hospitalisation with COVID-19: Not specified | |
| 103 (57.3%) | Mar 30––Apr 24, 2020 | 32416289 | During hospitalisation with COVID-19: Not specified | |
| 58 | Mar 3–Apr 3, 2020 | 32294339 | During hospitalisation with COVID-19: Not specified | |
|
Systematic review (11) |
205,938 | 2020 | 32730915 | Not specified: Not specified |
| 765 | 2020 | 32725449 | Not specified: Not specified | |
| 116 | 2020 | 32603770 | Long-term reported: Not specified | |
| 36 (80.5%) | Mar 25–May 20, 2020 | 32653111 | During COVID-19: Not specified | |
| 9086 (45.2%) | Jan–June, 2020 | 32561222 | Long-term reported: Not specified | |
| 1454 | Dec 2019-May 1, 2020 | 32574246 | Not specified: Not specified | |
| 1048 (50.4%) | Jan 1–Apr 10, 2020 | 32437679 | Following COVID-19: Not specified | |
| 235 | 2020 | 32422545 | Not specified: Not specified | |
| - | Up to May 10, 2020 | 32490966 | Not specified: Not specified | |
| 4014 | Jan 1–Apr 15, 2020 | 32345728 | During COVID-19: Not specified | |
| 765 | Dec 1, 2019–Mar 26, 2020 | 32299017 | During COVID-19: Not specified | |
| Meta-analysis (1) | ~ 4700 | Feb 7-May 17, 2020 | 32529575 | Not specified: Not specified |
|
Narrative review, brief report, perspective, research article (51) |
– | Feb 28–Aug 11, 2020 | 32776905, 32767055, 32758257, 32751841, 32729463, 32725545, 32720223, 32627524, 32683890, 32440692, 32672843, 32668062, 32628969, 32610334, 32655490, 32655489, 32491829, 32715280, 32587958, 32527073, 32581854, 32498691, 32492193, 32485101, 32486196, 32469504, 32474399, 32458193, 32574248, 32574247, 32442082, 32427468, 32424503, 32418055, 32427134, 32405259, 32405150, 32378030, 32417,235, 32417124, 32366614, 32643664, 32515379, 32352081, 32320066, 32343122, 32320211, 32266761, 32385132, 32104915, 32538857 | During COVID-19 and long-term COVID, as indicative: Not specified |
The facts indicate types of the studies in literatures, their publication timeline, sample size included in the studies, PubMed ID of the articles and status of the COVID-19 patients mentioned in the studies. The details of the literature PubMed ID with their full citation are presented in Table S1 under Supplementary File 1. The manually curated ‘neurological symptoms/manifestations’ from 103 selected literature are presented in Table S2 in Supplementary File 1.