Figure 4. Mean Systolic Blood Pressures by Treatment Group Comparing Trial Measurements With Outpatient Readings Extracted From the Electronic Health Record (EHR).

Estimates based on a linear mixed model with random intercepts for participant and clinic site, with years since randomization modeled using B-splines. Shaded areas denote pointwise 95% CIs. The trial phase and observational phase do not overlap for individual participants, but due to participants being randomized over time, there is an overlap in the trial and observational phase for the trial population when time is measured relative to the date of randomization. Trial phase encompasses follow-up through the end of study closeout visits (eFigure 1 in Supplement 2).