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. 2022 Sep 29;12:958065. doi: 10.3389/fonc.2022.958065

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Copyright © 2022 Zhu, Gao, Zhu, Han, Liu, Li, Liu, Wang, Zhang, Zhang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A–C) Axial MR images obtained in a 56-year-old patient with a PSA level of 4.2 ng/ml and with negative biopsy findings. T2WI (A) showed a heterogeneous encapsulated nodule in the left transition zone (arrow) and the ADC map (B) showed hypointensity (arrow). The ADC model (C) appeared false positive (red region). (D–F) Axial MR images obtained in a 64-year-old patient with a PSA level of 5.9 ng/ml and with negative biopsy findings. T2W (D) and ADC (E) showed a normal left central zone, while the ADC model (F) appeared false positive in this area (red mark). The biparametric model gave negative predictive values for both cases.