TABLE 4.
SarA-upregulated genes
| ORFa | Geneb | Patternc | Functiond | N315 ORFe | Role categoryf | Sar boxg |
|---|---|---|---|---|---|---|
| 3298 | capJ | 1 (2) | Capsule gene | SA0153 | Adaptation | |
| 1321 | aroC | 1 (1) | Chorismate synthetase | SA1299 | Amino acid metabolism | |
| 997 | hutG | 1 (1) | Arginase | SA2125 | Amino acid metabolism | Yes |
| 452 | metK | 1 (2) | S-Adenosylmethionine synthetase | SA1608 | Amino acid metabolism | |
| 2628 | pepF | 1 (4) | Peptidase | SA1216 | Amino acid metabolism | |
| 7 | sdhB | 1 (2) | l-Serine dehydratase | SA2319 | Amino acid metabolism | |
| 821 | 1 (2) | Acetyltransferase | SA1931 | Amino acid metabolism | Yes | |
| 1765 | epiF | 1 (2) | Epidermin-like biosynthetic cluster | Antibiotic production | ||
| 4746 | epiP | 1 (2) | Serine protease | Antibiotic production | ||
| 4442 | 1 (2) | Bacteriophage protein | SA1786 | Bacteriophage related | ||
| 3688 | 1 (7) | Predicted membrane protein | SA2436 | Bacteriophage related | ||
| 1973 | rodA | 1 (3) | Cell division membrane protein | SA1888 | Cell division | |
| 184 | femA | 1 (2) | mec resistance | SA1206 | Cell wall | |
| 2497 | tagF | 1 (2) | Glycosyl/glycerophosphate transferases | SA0244 | Cell wall | |
| 3495 | uppS | 1 (4) | Undecaprenyl diphosphate synthase | SA1103 | Cell wall | |
| 600 | 1 (3) | Putative glycosyltransferases | SA0523 | Cell wall | ||
| 4757 | 1 (2) | 6-Pyruvoyl-tetrahydropterin synthase | SA0666 | Coenzyme metabolism | ||
| 3095 | dnaG | 1 (2) | DNA primase | SA1391 | DNA replication | |
| 3733 | BH2391 | 1 (1) | Short-chain alcohol dehydrogenases | SA1123 | Lipid metabolism | |
| 3898 | crtN | 1 (2) | Putative phytoene dehydrogenase | SA2351 | Lipid metabolism | |
| 797 | purA | 1 (3) | Adenylosuccinate synthase | SA0016 | Nucleic acid metabolism | |
| 373 | pyrAA | 1 (1) | Carbamoyl-phosphate synthetase | SA1045 | Nucleic acid metabolism | |
| 783 | rpmH | 1 (1) | Ribosomal protein L34 | SAS093 | Ribosomal proteins | |
| 1118 | queA | 2 (4) | S-Adenosylmethionine | SA1466 | RNA modification | |
| 2444 | agrA | 1 (1) | agr response | SA1844 | Signal transduction | Upstream |
| 1426 | agrB | 1 (1) | agr response | SA1842 | Signal transduction | Yes |
| 2443 | agrC | 2 (2) | agr response | SA1843 | Signal transduction | Upstream |
| 1425 | agrD | 1 (1) | agr response | SAS066 | Signal transduction | Upstream |
| 2944 | phoP | 1 (1) | Response regulator | SA1516 | Transcriptional regulation | Yes |
| 5259 | 1 (3) | Transcriptional regulator, GntR family | SA0434 | Transcriptional regulation | ||
| 2852 | 1 (2) | Putative transcriptional regulator | SA1120 | Transcriptional regulation | ||
| 1545 | prfA | 1 (1) | Protein chain release factor A | SA1920 | Translation termination | |
| 4309 | fhuD | 1 (2) | Ferrichrome-binding periplasmic protein | SA2079 | Transport | |
| 614 | gltS | 1 (1) | Glutamate permease | SA2135 | Transport | |
| 2601 | opp-2B | 1 (4) | Putative oligopeptide transporter | SA1214 | Transport | Yes |
| 271 | 1 (3) | Putative permease | SA0099 | Transport | ||
| 272 | 1 (2) | Putative transport | SA0100 | Transport | Upstream | |
| 4602 | 1 (2) | Bmr-like protein | SA2241 | Transport | ||
| 4200 | 1 (2) | SA0085 | Unknown | |||
| 992 | 1 (3) | Conserved hypothetical | SA0174 | Unknown | ||
| 243 | 1 (1) | Conserved hypothetical | SA0350 | Unknown | ||
| 2095 | 1 (1) | Hypothetical protein | SA0453 | Unknown | Yes | |
| 2634 | 1 (3) | Unknown | SA0754 | Unknown | ||
| 4370 | 1 (2) | SA1037 | Unknown | |||
| 890 | 1 (2) | Conserved hypothetical | SA1240 | Unknown | ||
| 2479 | 1 (2) | Conserved hypothetical | SA1275 | Unknown | ||
| 2782 | 1 (2) | Hypothetical protein | SA1319 | Unknown | ||
| 2785 | 2 (6) | Conserved hypothetical | SA1388 | Unknown | ||
| 5283 | 1 (2) | Conserved hypothetical | SA1611 | Unknown | ||
| 5066 | 1 (2) | Conserved hypothetical | SA1684 | Unknown | ||
| 4929 | 1 (2) | Hypothetical protein | SA1889 | Unknown | ||
| 5521 | 1 (2) | Hypothetical protein | SA1928 | Unknown | ||
| 2505 | 1 (2) | Hypothetical protein | SA1944 | Unknown | ||
| 1555 | 1 (2) | Acetyltransferase | SA2161 | Unknown | ||
| 9 | 1 (1) | Hypothetical protein | SA2321 | Unknown | ||
| 37 | 1 (1) | Hypothetical protein | SA2343 | Unknown | ||
| 3982 | 1 (2) | Conserved hypothetical | SA2491 | Unknown | ||
| 644 | 1 (1) | Hypothetical protein | SAS016 | Unknown | ||
| 2105 | 1 (2) | Conserved hypothetical | Unknown | |||
| 2275 | 1 (1) | Hypothetical protein | Unknown | |||
| 4044 | fnbA | 1 (7) | Fibronectin binding protein A | SA2291 | Virulence factors | |
| 3636 | fnbB | 1 (3) | Fibronectin binding protein B | SA2291 | Virulence factors | |
| 4061 | hla | 1 (1) | Alpha-toxin | SA1007 | Virulence factors | Yes |
| 4578 | hld | 2 (2) | Delta-hemolysin | SAS065 | Virulence factors | Yes |
| 1928 | hlgB | 1 (5) | Gamma-hemolysin component B | SA2209 | Virulence factors | Upstream |
| 1927 | hlgC | 1 (2) | Gamma-hemolysin component C | SA2208 | Virulence factors | Yes |
| 366 | hsa | 1 (X) | Homolog of streptococcal hemagglutinin | SA2447 | Virulence factors | |
| 4374 | map | 3 (3) | Map protein | SA2006 | Virulence factors | |
| 1175 | pls | 1 (2) | Related to Pls and accumulation-associated proteins, LPXTG motif | SA2284 | Virulence factors | |
| 2343 | sdrc | 2 (2) | Surface protein (SdrC) | Virulence factors | ||
| 2037 | set9 | 1 (4) | Staphylococcal exotoxin | SA0385 | Virulence factors | |
| 5329 | splA | 1 (2) | Serine protease | SA1631 | Virulence factors | Yes |
| 2929 | splB | 1 (1) | Serine protease | SA1630 | Virulence factors | Upstream |
| 324 | splD | 1 (1) | Serine protease | SA1628 | Virulence factors | Upstream |
| 327 | splF | 2 (2) | Serine protease | SA1627 | Virulence factors | Upstream |
| 4523 | 2 (2) | Phenol soluble modulin beta 2 | Virulence factors |
a
Designated S. aureus GeneChip ORF number.
b
Previously described gene name.
c
Many genes are represented on the S. aureus GeneChip in a redundant manner as full or partial fragments. Values are the number of times a gene transcript was identified as fitting a pattern (number of times the gene was either partially or completely represented on the GeneChip).
d
Previously described gene product function.
e
Corresponding designated S. aureus strain N315 gene (20).
f
Expected metabolic role.
g
Yes, putative Sar box identified within the gene's promoter region. Upstream, the gene is expected to be part of an operon with a potential Sar box located in an upstream promoter region.