Table 2.

List of cancer types with lncRNAs expressions down and upregulated and their Notch-target gene(s)

Cancer	LncRNA	Expression	Notch-target gene(s)	Refs.
NSCLC	LET NBR2	Downregulated	Notch1 intracellular domain Notch1	[67] [69]
	Xist Lbx2-as1 PVT1 LINC01783 FEZF1-AS1	Upregulated	Notch1 via sponging miR-137 Notch1, p21 and Hes1 Notch1, NICD and Hes1 via YAP1 activation DLL-1 via targeting miR-432-5p Notch1 via sponging miR-34a	[79] [80] [81] [82] [27]
Lung adenocarcinoma	LINC01123	Upregulated	Notch1 via sponging miR-449b-5p	[120]
Osteosarcoma	NBR2 CEBPA-AS1	Downregulated	Notch1 Hes1 and RBPJ	[68] [74]
	SNHG12 CRNDE	Upregulated	Notch2 via sponging miR195-5p Notch1, JAG1 and EMT related proteins	[107] [109]
Endometrial	MEG3	Downregulated	Notch1, Hes1	[70]
	ROR	Upregulated	Notch1 via regulating expression of miR34a	[95]
Gastric	MIR22HG	Downregulated	Notch2 signaling	[71]
	NALT1 SNHG1 Linc01555 DLEU2	Upregulated	Notch1 Notch1 via sponging miR-15b Notch1, Notch2, DLL3 and Hes1 Notch2	[83] [85] [86] [87]
Hepatocellular	LincRNA-p21 LINC00261	Downregulated	NICD and Hes1 Notch1 and Hes1	[72] [73]
	LNCRNA00673	Upregulated	Notch1 and Notch3	[113]
Glioma	RAMP2-AS1	Downregulated	Notch3	[75]
	FEZF1-AS1 Linc-OIP5 ZFAS1 LINC01152 PlncRNA-1 LINC01410	Upregulated	Notch1via sponging miR-34a JAG1, Notch1 and Hes1 Hes1 and NICD Notch pathway Notch1, JAG1 and Hes1 Notch2	[98] [100] [102] [103] [104] [105]
Bladder	HCG18	Downregulated	Notch1	[76]
Pancreatic	Xist HOTAIR RP11-567G11.1 HCG11	Upregulated	Notch1 via sponging miR-137 Notch3 via sponging miR-613 JAG1, hes1, hes5 and MATH1 NICD and Hes1 via sponging miR-579-3p	[78] [93] [110] [112]
Melanoma	PAUPAR	Downregulated	Hes1	[77]
	BANCR	Upregulated	Notch2 via sponging miR-204	[121]
Cervical	DLEU2 SRA DARS-AS1 HOTAIR HOXA-AS2	Upregulated	Notch1 and RBPJ through impeding p53 expression Notch1, Hes1 and p300 JAG1 via sponging miR-628-5p Notch1, Hes1 and p300 NICD	[88] [89] [90] [92] [124]
CRC	FOXD2-AS1 FAM83H‑AS1 LINC00152 DSCAM-AS1 LINC01198 LINC00707 ENST00000455974 GNAS-AS1 & RP11-89K10.1 Lnc34a UICLM	Upregulated	NICD, Hes1 Notch1 and Hes1 Notch1 via sponging miR-139-5p Notch1 via sponging miR-137 Notch1, p300 and Hes1 Notch3 & TM4SF1via sponging miR-206 JAG2 Hes1 Notch pathway via sponging miR-34a Notch1	[125] [126] [127] [128] [129] [130] [131] [132] [133, 134] [135]
Breast	Linc-OIP5 SNHG3 SNHG7	Upregulated	JAG1 Notch by binding to miR-154-3p Notch1via sponging miR-34a	[101] [28] [106]
Retinoblastoma	HOTAIR ROR	Upregulated	Notch1, JAG1 Notch1 via sponging miR-32	[91] [94]
Prostate	GHET1 FEZF1-AS1 DANCR	Upregulated	Notch1 and HIF-1 α via negative regulation of KLF2 Notch1, p21 and Hes1 JAG1 via sponging miR-34a-5p	[96] [97] [99]
Tongue	UCA1	Upregulated	JAG1 and Notch1 via sponging miR-124	[114]
Ovarian	MALAT1 DLX6-AS1	Upregulated	Notch1 pathway Notch1, p21 and Hes1	[115] [116]
Renal	RP11-567G11.1	Upregulated	JAG1, hes5 and Hey1	[111]
Acute leukemia	NALT1	Upregulated	Notch1	[84]
Nasopharyngeal	SNHG12	Upregulated	Notch pathway	[108]
Neuroblastoma	LncND	Upregulated	Notch1&Notch2 via sponging miR-143-3P	[117]
Oral squamous	HNF1A-AS1	Upregulated	Notch1 and hes1	[118]
Hemangioma (infantile)	MEG8 Linc00152	Upregulated	Notch2 via sponging miR-497-5p Notch1, Hes1 and hey1	[123] [122]
Papillary thyroid	CCAL	Upregulated	Notch1 signal	[119]