Table 8.

Effects ^a of antimicrobial peptides (AMPs) on various parameters in piglets.

AMP	Dose	Replicates	Pathogenic Challenge	Endpoints b						Refs.
				GP	FT/D	GA	EB	IS	GM
WK3	2 mg/kg body weight (injection)	8 piglets	ETEC F4	+	+	+	nm	+	(+)	[224]
WK3	50 mg/kg feed	8 piglets	ETEC F4	+	+	+	nm	+	+	[226]
Cathelicidin-BF	0.6 mg/kg body weight (intraperitoneally)	3 pens with 6 piglets	nm	+	+	+	+	+	nm	[227]
KR-32		6 piglets	nm	nm	+	nm	nm	+	nm	[228]
Microcin J25	0,5; 1; 2 mg/kg feed	6 pens with 6 piglets	nm	+	+	nm	+	+	+	[223]
Porcine beta-defensin-2	1 mg/day orally	10 or 5 piglets	ETEC F4	+	nm	+	nm	+	+	[229]
Porcine beta-defensin-2	1; 5; 15 g /kg feed	3 pens with 10 piglets	nm	+ (day 1 to 28 post-weaning)	+ (day 1 to 28 post-weaning)	+ (day 28 post-weaning)	nm	nm	nm	[230]
Plectasin	60 mg/kg feed	6 piglets	nm	+ (day 1 to 21 post-weaning)	+	+	+	nm	+	[231]
Cecropin AD	400 mg/kg feed	8 piglets	ETEC F4	+	+	+	nm	+/−	+	[221]
Colicin E1	11; 16.5 mg/kg feed	8 piglets	ETEC F18	+ (high dose group)	+ (high dose group)	nm	nm	+ (high-dose group)	nm	[232]
Lactoferrin	1 g/kg feed	3 pens with 10 piglets		+ (day 1 to 28 post-weaning)	+ (day 1 to 28 post-weaning)	+ (day 28 post-weaning)	nm	nm	nm	[233]
Lactoferrin+ cecropin+ defensing+ and plectasin	2; 3 g/kg feed	84 pens with 11 piglets (5 farms)	nm	+ (day 1 to 32 post-weaning)	+ (day 1 to 32 post-weaning)	nm	nm	nm	nm	[234]
Lactoferrampin-lactoferricin	100mg/kg feed	10 piglets	nm	+	+	nm	+	+	nm	[235]
Musca domestica larvae AMP+ porcine defensin	400mg/kg feed	4 pens with 3 piglets	nm	+	+	nm	nm	NS	+ (day 28 post-weaning)	[236]

^a Effects. +: positive effect; −: negative effect; NS: Non-significant effect; nm: not measured. ^b GP: growth performance; ND: digestibility; FT/D: faecal trait/diarrhoea; GA: gut architecture/histology; EB: epithelial barrier; IS: immune system; GM: gut microbiology.