Table 5. Hematological and Enzymological Parameters after Acute and Sub-Acute Toxicity Studies of Alkali-Extracted Mandua Starch (AMS) and Chemically Modified Cross-Linked Mandua Starch (ECC-MS).
| mean ± SDa |
||||||
|---|---|---|---|---|---|---|
| acute toxicity study (dose: 2000 mg/kg body wt of animal) |
sub-acute toxicity study (dose: 1000 mg/kg body wt of animal) |
|||||
| sl. no. | parameters | AMS | ECC-MS | AMS | ECC-MS | control |
| 1. | hemoglobin (g/dL) | 14.45 ± 0.50 | 14.63 ± 0.42 | 14.18 ± 0.21 | 13.64 ± 0.30 | 13.50 ± 0.68 |
| 2. | WBC (×103/mm3) | 8.11 ± 0.32 | 9.38 ± 0.58 | 8.81 ± 0.42 | 9.03 ± 0.38 | 8.89 ± 0.30 |
| 3. | RBC (×106/mm3) | 8.08 ± 0.44 | 8.05 ± 0.30 | 8.39 ± 0.29 | 8.05 ± 0.24 | 7.61 ± 0.45 |
| 4. | neutrophils (×103/mm3) | 2.60 ± 0.29 | 2.70 ± 0.07 | 2.66 ± 0.17 | 2.68 ± 0.19 | 2.56 ± 0.55 |
| 5. | lymphocytes (×103/mm3) | 6.83 ± 0.87 | 7.26 ± 0.49 | 7.49 ± 0.33 | 8.03 ± 0.29 | 7.70 ± 0.81 |
| 6. | eosinophils (×103/mm3) | 0.05 ± 0.01 | 0.05 ± 0.00 | 0.05 ± 0.00 | 0.04 ± 0.00 | 0.05 ± 0.01 |
| 7. | monocytes (×103/mm3) | 0.02 ± 0.00 | 0.03 ± 0.00 | 0.03 ± 0.00 | 0.02 ± 0.00 | 0.023 ± 0.00 |
| 8. | basophiles (×103/mm3) | 0 ± 0.00 | 0 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.0 ± 0.00 |
| 9. | SGOT (IU/L) | 42.47 ± 2.13 | 39.45 ± 1.98 | 38.07 ± 1.80 | 36.56 ± 1.93 | 36.40 ± 1.21 |
| 10. | SGPT (IU/L) | 25.91 ± 3.74 | 27.85 ± 1.87 | 29.00 ± 0.99 | 29.75 ± 1.60 | 31.41 ± 1.08 |
| 11. | serum creatinine | 0.41 ± 0.06 | 0.38 ± 0.00 | 0.39 ± 0.01 | 0.40 ± 0.01 | 0.38 ± 0.01 |
| 12. | serum urea | 40.98 ± 2.90 | 36.68 ± 0.28 | 39.74 ± 0.98 | 41.51 ± 1.41 | 39.52 ± 0.58 |
a
Different model values were presented as mean ± SD.