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. 2022 Sep 28;7(40):35387–35445. doi: 10.1021/acsomega.2c03171

Table 7. Various GO-Based Scaffolds for Neural Tissue.

Entry Scaffolds Biological activity/Mechanical strength Refs
1 GO sheets G-NFs (stable electrical conductivity, soft physical feature, and good biocompatibility). (153)
2 Rolled GO foams hNSCs (human neural stem cells) proliferate and differentiate effectively throughout the pores and interfaces of the scaffold. (154)
3 GO acrylate sheets–CNT– poly(ethyleneglycol) acrylate–oligo(polyethyleneglycol fumarate) hydrogel Cytotoxicity testing on PC12 cells demonstrated no significant cytotoxicity, and the hydrogel gives an ideal surrounding for neural outgrowth and cellular propagation. These findings imply that the hydrogel might be used in neural tissue engineering. (155)
4 GO-coated PLLA-aligned nanofibers The surface roughness and hydrophilicity of aligned PLLA nanofibers were enhanced by GO coating. It improved cell orientation and SC growth and stimulated PC12 neurite development and cell differentiation. (156)
5 GO-based GPS having hierarchical structures Neuroprosthetics and biosensors. (157)
6 GO microfiber Effective neural development substrate for the CNS after injury. (18)
7 GO–PLGA hybrid nanofiber Improves functional locomotor recovery, decreased the formation of cavity, and increased the number of neurons at the injury site. (22)
8 GO aerogel The development of fibro glandular tissues and structures is inhibited by GO in the neural canal. The multiplication and expansion of neural stem cells. (158)
9 GO and electroactive rGO-based composite Enhances electrical conductivity of the scaffold and enhances metabolic activity and proliferation. (159)
10 GO foam (GOF)-based 3D scaffold The hNSCs were effectively proliferated and differentiated throughout the scaffold because of the cross-section of the rolled GOF. Increased cell proliferation and faster neuron development were observed after electrical stimulation of hNSCs. (20)