Table 2.

Successful cases reported using amantadine, therapy regimen, and outcome.

Patient’s diagnosis	Reference	Number of patients	Therapy regimen	Outcome
Bipolar disorder and catatonia	Ene-Stroescu et al. (2014a)	1	Amantadine (Dose notdisclosed) + Lorazepam + Carbamazepine	Full response after 72 h
Catatonia	Goetz et al. (2013)	1	ECT + Amantadine 250 mg/day	Discharged after 6 weeks. Full recovery
Catatoniain schizophrenia and schizo affective disorder	de Lucena et al. (2012)	5	Case 1: Clozapine + 400 mg of amantadine Case 2: Amantadine protocol Case 3: Amantadine protocol Case 4: Amantadine protocol Case 5: Amantadine protocol *Protocol: up to 600 mg of amantadine daily for 4 weeks	Case 1: Recovery on the 14th day with clozapine Case 2: Recovery by the 10th day Case 3: Recovery at the end of the protocol Case 4: Full recovery on the 8th day Case 5: Acceptable behavior by the 45th day
Catatonia and schizophrenia	Babington and Spiegel (2007)	1	Lorazepam+chlorpromazine+Amantadine 200 mgday	Fast recovery after 48 h of amantadine
Westphal variant Huntington disease and refractory catatonia	Merida-Puga et al. (2011)	1	Antipsychotics + ECT+L-dopa + Amantadine 300 mg/day	Not available
Catatonia and depressive disorder	Hervey et al. (2013)	1	Lorazepam + amantadine 200 mg/day	Recovery once amantadine was initiated
Catatonia, schizophrenia, and progressive diffuse cerebral atrophy	Ene-Stroescu et al. (2014b)	1	Clozapine+lorazepam+divalproex+amantadine (dose not specified)	Maximal response after 8 weeks of treatment
Catatonia in high-functioning ASD	Ellul et al. (2015)	1	Initial regimen of Zolpidem+lorazepamthen a 1-week washout followed by amantadine 200 mg/day	Maximal recovery after 2 weeks with amantadine
Akinetic catatonia	Northoff et al. (1997)	3	Case 1: Three IV infusions of amantadine 500 mg/dose Case 2: Two IV infusions of amantadine 500 mg/dose Case 3: Two IV infusions of amantadine 500 mg/dose	Case 1: Recovery after the third infusion of amantadine Case 2: Recovery after the second infusion Case 3: Recovery after the third infusion	#x02014;needed lorazepam to treat aggressive and anxious behavior