TABLE 4.

Calculated slopes (mean +95% confidence intervals) and x-intercepts for the anti-allodynic and hypothermic effects of vehicle (VEH)- and decursinol (DOH)-treated groups across day in neuropathic mice. Linear regression analyses were used to determine the slopes from the daily tolerance curves following once-daily treatment with either vehicle (VEH) or decursinol (DOH) across 14 days of once-daily treatment in mice with neuropathic pain. The slopes were extrapolated to determine the x-intercept indicative of when the response following treatment would be 0. Values shown are the slopes and extrapolated x-intercepts and 95% confidence intervals for vehicle and decursinol treated mice (N = 12/group). ∞ = values that could not be calculated/were listed as infinity. Significance denotes a significant difference in the slope from 0.

Assay	Drug	Slope	X-intercept	Significance
		Mean (CI)	Mean (CI)
Von Frey	VEH	−0.03109 (-0.0476- -0.0146)	84.08 (57.48–170.6)	p = 0.0015**
—	DOH	−4.370 (-4.973–3.765)	18.54 (17.1–20.4)	p < 0.0001****
Body Temperature	VEH	0.01823 (-0.1102–0.1467)	-143.0 (-∞--10.88)	p = 0.7625
—	DOH	0.6299 (0.3638–0.8960)	17.99 (14.55–25.98)	p = 0.0002***