Table II.
Parameters in the local hyperthermia and cryotherapy groups analysed with stepwise multiple logistic regression
| Factors | Local hyperthermia | Cryotherapy | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | Clearance n (%) | COR (95% CI) | p-value | AOR (95% CI) | p-value | N | Clearance n (%) | COR (95% CI) | p-value | AOR (95% CI) | p-value | |
| Age | ||||||||||||
| <24 years | 166 | 119 (71.7) | 2.3 (1.4–3.5) | < 0.001 | 1.5 (0.9–2.5) | 0.097 | 137 | 86 (62.8) | 1.2 (0.8–2.0) | 0.376 | ||
| 24–30 years | 155 | 90 (58.1) | 1.2 (0.8–1.9) | 0.342 | 1.1 (0.7–1.7) | 0.729 | 158 | 83 (52.3) | 0.8 (0.5–1.3) | 0.386 | ||
| >30 years | 163 | 86 (52.8) | 1.00 | 1.00 | – | 139 | 80 (57.6) | 1.0 | ||||
| Sex, n | ||||||||||||
| Male | 225 | 140 (63.1) | 1.18 (0.8–1.7) | 0.381 | – | – | 198 | 121 (61.1) | 1.3 (0.9–2.0) | 0.141 | ||
| Female | 259 | 155 (59.4) | 1.00 | 236 | 128 (54.2) | 1.0 | ||||||
| Location of lesion | ||||||||||||
| Toes | 313 | 196 (62.6) | 1.8 (1.0–3.6) | 0.068 | 2.3 (1.1–4.7) | 0.024 | 278 | 152 (54.6) | 0.6 (0.3–1.4) | 0.241 | ||
| Heel | 57 | 44 (77.2) | 3.7 (1.6–9.0) | 0.003 | 4.3 (1.7–11.0) | 0.002 | 65 | 35 (53.8) | 0.6 (0.3–1.5) | 0.271 | ||
| Arch | 42 | 25 (59.5) | 1.6 (0.7–3.9) | 0.276 | 1.7 (0.7–4.3) | 0.270 | 37 | 26 (70.3) | 1.2 (0.4–3.4) | 0.680 | ||
| Sole | 32 | 11 (34.4) | 0.6 (0.2–1.5) | 0.263 | 0.8 (0.3–2.3) | 0.730 | 22 | 15 (68.2) | 1.1 (0.4–3.6) | 0.845 | ||
| Others | 40 | 19 (47.5) | 1.00 | 1.00 | – | 32 | 21 (65.6) | 1.0 | ||||
| Diameter of lesion | ||||||||||||
| ≤4 mm | 116 | 91 (78.4) | 3.5 (2.1–5.8) | < 0.001 | 2.3 (1.3–4.1) | 0.003 | 217 | 140 (64.5) | 2.4 (1.4–4.3) | 0.002 | 2.2 (1.3–3.9) | 0.005 |
| 4.1–7.9 mm | 144 | 89 (61.8) | 1.5 (1.0–2.3) | < 0.049 | 1.3 (0.8–2.1) | 0.223 | 149 | 80 (53.7) | 1.6 (0.9–2.8) | 0.132 | 1.5 (0.8–2.7) | 0.174 |
| ≥8 mm | 224 | 115 (57.7) | 1.00 | 1.00 | – | 68 | 29 (42.6) | 1.0 | 1.0 | |||
| Number of lesions | ||||||||||||
| 1–3 | 230 | 145 (63.0) | 1.2 (0.8–1.7) | 0.369 | – | – | 220 | 124 (56.4) | 0.9 (0.6–1.3) | 0.666 | ||
| ≥4 or mosaic | 254 | 150 (59.1) | 1.00 | 214 | 125 (58.4) | 1.0 | ||||||
| Duration | ||||||||||||
| ≤12 months | 195 | 147 (75.4) | 2.9 (2.0–4.3) | < 0.001 | 2.4 (1.5–3.8) | < 0.001 | 220 | 142 (64.5) | 1.8 (1.2–2.7) | 0.002 | 1.7 (1.1–2.5) | 0.008 |
| >12 months | 289 | 148 (51.2) | 1.00 | 1.00 | – | 214 | 107 (50.0) | 1.0 | 1.0 | |||
COR: crude OR; AOR: adjusted odds ratio with p ≤ 0.2 in univariate analysis were entered in multivariate Cox regression model; 95% CI: 95% confidence interval. The population of local hyperthermia group and cryotherapy group were analyzed by modified intention-to-treat.