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. 2022 Sep 13;50(5):133. doi: 10.3892/ijmm.2022.5189

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Copyright: © Tran et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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The phosphorylation of histone H3 at serine 10 and the localization of Aurora B kinase were disrupted in OVCAR-8 cancer cells treated with oxostephanine and VX-680. (A) H3S10ph (green) was suppressed in the presence of oxostephanine (5 µM) and VX-680 (0.2 µM) for 15 h. In the case of synchronization to the pro-metaphase, cells were pre-treated with paclitaxel (0.3 µg/ml) for 8 h, then incubated with the two substances as mentioned above. (B) Aurora B was deconcentrated on the chromosomal centromeres following treatment with the substances. (C) The expression of Aurora A and Aurora B was decreased at the mRNA level following treatment with oxostephanine and VX-680. ^*P<0.05, vs. control.