Table 3. Cytokine and growth factor upstream regulators of differentially expressed genes of super ovulated and artificially inseminated cows (SOV+AI) compared with super ovulated cows without AI.
| Upstream regulator | Molecule type | Predicted activation state | Activation z-score |
|---|---|---|---|
| IL1A | cytokine | Activated | 2.114 |
| CNTF | cytokine | Activated | 2.173 |
| IL1B | cytokine | Activated | 2.203 |
| CSF3 | cytokine | Activated | 2.224 |
| WNT1 | cytokine | Activated | 2.63 |
| EDN1 | cytokine | Activated | 3.237 |
| LIF | cytokine | Activated | 3.264 |
| IL6 | cytokine | Activated | 3.37 |
| OSM | cytokine | Activated | 3.744 |
| IGF1 | growth factor | Activated | 2.116 |
| FGF2 | growth factor | Activated | 2.155 |
| CSHL1 | growth factor | Activated | 2.375 |
| GH1 | growth factor | Activated | 2.566 |
| TGFB2 | growth factor | Activated | 2.645 |
| EGF | growth factor | Activated | 2.735 |
| TGFB1 | growth factor | Activated | 3.134 |
| ANGPT2 | growth factor | Activated | 3.161 |
| GDF2 | growth factor | Activated | 3.278 |
| FLT3LG | cytokine | Inhibited | –2.828 |
| IL21 | cytokine | Inhibited | –2.74 |