TABLE 2.

The prognostic value of single CpG of FRAS1 and FREM2 in KIRC by MethSurv (p < 0.05).

Gene	Relation to island	Genomic region	CpG site	Best_split	HR	CI	LR test p value
FRAS1
	Open_Sea	Body	cg20948271	q25	0.41	(0.276; 0.611)	2.95E-05
	Open_Sea	Body	cg17512,802	mean	2.544	(1.65; 3.922)	7.49E-06
	Island	Body	cg02494368	mean	0.441	(0.286; 0.681)	0.000104156
	Open_Sea	Body	cg14091154	q25	0.47	(0.314; 0.704)	0.000486185
	Open_Sea	Body	cg04091555	q25	0.51	(0.341; 0.764)	0.001728597
	N_Shore	Body	cg03877364	median	1.856	(1.253; 2.75)	0.001735773
	Island	TSS200	cg11073571	q75	0.423	(0.244; 0.733)	0.000734126
	Island	TSS200	cg11940149	q75	0.428	(0.247; 0.741)	0.000872463
	Island	Body	cg16678047	q25	2.328	(1.341; 4.041)	0.000980456
	Island	Body	cg04366385	q75	0.435	(0.251; 0.752)	0.001079704
FREM2
	Open_Sea	Body	cg26881651	mean	0.489	(0.333; 0.719)	0.000342
	Open_Sea	3′UTR	cg18595137	q25	2.426	(1.38; 4.265)	0.000642
	N_Shore	TSS1500	cg05542757	q75	1.877	(1.257; 2.804)	0.003037
	Island	1stExon	cg12844784	q25	2.383	(1.306; 4.348)	0.001604
	Open_Sea	Body	cg03623599	q25	1.926	(1.171; 3.17)	0.00591
	N_Shore	TSS200	cg21662160	q75	1.607	(1.067; 2.419)	0.02758
	Island	1stExon	cg26063106	q75	1.597	(1.063; 2.398)	0.028575
	N_Shore	TSS1500	cg25822402	q75	0.575	(0.352; 0.941)	0.020161
	S_Shelf	1stExon	cg19582,128	mean	0.647	(0.436; 0.96)	0.034219
	Island	1stExon; 5′UTR	cg24087887	q25	1.668	(1.024; 2.715)	0.030612

Abbreviations: KIRC, kidney renal clear cell carcinoma; HR, hazard ratio; LR, test, likelihoodratio test.