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. 2022 Jun 2;31(20):3458–3477. doi: 10.1093/hmg/ddac118

Figure 1.

Figure 1

Different sALS metabotypes show distinct gene expression profiles and transcriptional responses to EH301. (A) Volcano plot of DEGs in sALS1 (left) versus control and sALS2 (right) versus control fibroblasts (n = 6 per group). Red dots represent DEGs with P-value < 0.05 after FDR adjustment. Known ALS-related disease genes are labeled. (B) Gene ontology pathways with significantly enriched BPs and MFs of upregulated and downregulated DEGs in sALS1compared to control. (C) Venn diagram of DEGs with P-value < 0.05 after FDR adjustment modified by EH301 in control (green), sALS1 (blue) and sALS2 (red) fibroblasts (n = 6 per group). (D) Gene ontology pathways significantly enriched in EH301 treated controls (green) and sALS1 (blue) fibroblasts, (n = 6 per group), all DEGs with P-value < 0.05 after FDR adjustment were included in the analysis.