Table 2.

Association of the previously identified risk loci for AAA with abdominal aortic diameter

SNP	Nearest gene	A1/A2	β a	P-value b
GWAS
rs602633	PSRC1-CELSR2-SORT1	T/G	0.002	0.32
rs4129267	IL6R	T/C	-0.001	0.47
rs10757274	CDKN2BAS1/ANRIL	A/G	-0.006	1.71 × 10−4
rs10985349	DAB2IP	T/C	-0.001	0.58
rs6511720	LDLR	T/G	0.001	0.74
rs1795061	SMYD2	T/C	0.002	0.35
rs9316871	LINC00540	A/G	0.002	0.35
rs3827066	PCIF1-ZNF335-MMP9	T/C	0.002	0.44
rs2836411	ERG	T/C	0.003	0.036
rs7255	AC012065.7/LDAH	C/T	0.003	0.08
rs10023907	MEPE	T/C	0.003	0.07
rs3176336	CDKN1A	A/T	-0.002	0.21
rs10808546	RP11-136O12.2/TRIB1	T/C	-0.001	0.38
rs1412445	LIPA	T/C	-0.001	0.46
rs964184	ZNF259/APOA5	C/G	0.001	0.52
rs4936098	ADAMTS8	A/G	-0.003	0.03
rs35254673	CRISPLD2	A/G	0.002	0.29
rs4401144	CTAGE1	T/C	0.003	0.07
rs429358	APOE	T/C	0.001	0.57
rs11591147	PCSK9	T/G	0.004	0.72
rs118039278	LPA	A/G	0.001	0.69
rs55958997	CHRNA3	A/C	-0.001	0.54
rs73149487	ABHD16B	T/G	-0.0008	0.86
Candidate-gene studies
rs599839	SORT1	A/G	-0.001	0.46
rs7529229	IL6R	T/C	0.001	0.48
rs6743376	IL1RN	A/C	0.0001	0.93
rs1542176		T/C	-0.0006	0.68
rs10455872	LPA	A/G	-0.002	0.52
rs3798220		T/C	0.007	0.26
rs5186	AGTR1	A/C	-0.002	0.17
rs1036095	TGFBR2	C/G	0.001	0.53
rs764522		C/G	-0.003	0.08

A1: Coded allele; A2: Non-coded allele; ABHD16B: abhydrolase domain containing 16B; CDKN1A: cyclin dependent kinase inhibitor 1A; CELSR2: cadherin EGF LAG seven-pass G-type receptor 2; CHRNA3: cholinergic receptor nicotinic alpha 3 subunit; Chr: Chromosome; CRISPLD2: cysteine rich secretory protein LCCL domain containing 2; CTAGE1: cutaneous T cell lymphoma-associated antigen 1; DAB2IP: DAB2 interacting protein; ERG: ETS transcription factor ERG; LIPA: lipase A, lysosomal acid type; LPA: lipoprotein(A); MEPE: matrix extracellular phosphoglycoprotein; MMP: matrix metallopeptidase; PCIF1: phosphorylated CTD interacting factor 1; PSRC1: proline and serine rich coiled-coil 1; SMYD2: SET and MYND domain containing 2; SORT1: Sortilin 1; TRIB1: tribbles pseudokinase 1; P-value threshold = 0.003.

^aBeta coefficients from combined AAD meta-analysis.

^b P-value from combined AAD meta-analysis.