Table 4.
Mendelian randomization results for each risk factor
| Systolic blood pressure | |||
|---|---|---|---|
| Method | Estimate | P-value | P-value heterogeneity (IVW) |
| IVW | −0.001 | 0.2 | 0.04 |
| MR-Egger | 0.001 | 0.8 | - |
| MR-Egger (intercept) | 0 | 0.6 | - |
| Weighted median | 0.0001 | 0.9 | - |
| Diastolic blood pressure | |||
| IVW | −0.001 | 0.6 | 0.2 |
| MR-Egger | −0.002 | 0.5 | - |
| MR-Egger (intercept) | 0 | 0.6 | - |
| Weighted median | 0.001 | 0.8 | - |
| Pulse pressure | |||
| IVW | −0.003 | 0.02 | 0.02 |
| MR-Egger | −0.009 | 0.04 | - |
| MR-Egger (intercept) | 0 | 0.1 | - |
| Weighted median | −0.003 | 0.06 | - |
| Smoking | |||
| IVW | 0.02 | 0.3 | 0.03 |
| MR-Egger | 0.01 | 0.9 | - |
| MR-Egger (intercept) | 0 | 0.9 | - |
| Weighted median | −0.006 | 0.8 | - |
| LDL | |||
| IVW | −0.005 | 0.2 | 0.04 |
| MR-Egger | −0.004 | 0.5 | - |
| MR-Egger (intercept) | 0.0001 | 0.8 | - |
| Weighted median | −0.006 | 0.3 | - |
| HDL | |||
| IVW | −0.002 | 0.9 | 0.002 |
| MR-Egger | −0.02 | 08 | - |
| MR-Egger (intercept) | 0 | 0.8 | - |
| Weighted median | 0.009 | 0.7 | - |
| Triglycerides | |||
| IVW | −0.02 | 0.2 | 0.2 |
| MR-Egger | −0.16 | 0.008 | - |
| MR-Egger (intercept) | 0.003 | 0.01 | - |
| Weighted median | −0.03 | 0.1 | - |
| Height | |||
| IVW | 0.03 | 0.0001 | 0.05 |
| MR-Egger | 0.07 | 0.0001 | - |
| MR-Egger (intercept) | −0.001 | 0.008 | - |
| Weighted median | 0.03 | 0.0001 | - |
| BMI | |||
| IVW | 0.01 | 0.0001 | 0.06 |
| MR-Egger | 0.004 | 0.3 | - |
| MR-Egger (intercept) | 0.001 | 0.001 | - |
| Weighted median | 0.004 | 0.26 | - |
BMI: body mass index; HDL: high-density lipoprotein; IVW: inverse-variance weighting; LDL: low-density lipoprotein; MR: Mendelian randomization.