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. 2022 Oct 12;21:15330338221131647. doi: 10.1177/15330338221131647

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© The Author(s) 2022

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Biogenesis of EVs. Microvesicles bud directly from plasma membrane, whereas exosomes arise from multivesicular bodies. EVs interact with target cells through three mechanism: (1) EVs fusion with transfer of their cargos; (2) EVs endocytosis and release of their cargos; (3) Receptor ligand interaction with activation of signal transduction pathways. Figure created with BioRender.com (2022).

Abbreviation: EVs, extracellular vesicles.