Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Oct 12;21:15330338221131647. doi: 10.1177/15330338221131647

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

PMC Copyright notice

Figure 4. — CAFs transfer their cargos to breast cancer cells through EVs supporting tumor growth and the acquisition of an aggressive phenotype. Tumor development is regulated by EVs through the induction of invasion, proliferation, migration and EMT. CAFs release EVs that mediate changes in metabolism, immune modulation and chemoresistance in breast cancer cells, and modulate the expression of ECM components. Figure created with BioRender.com (2022).

Abbreviations: EVs, extracellular vesicles; CAFs, cancer-associated fibroblasts; ECM, extracellular matrix.