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. 2022 Sep 28;16:1013363. doi: 10.3389/fnins.2022.1013363

TABLE 1.

Neurological disorders associated with olfactory loss.

Neurological disorder References N Olfactory test
22q11 deletion syndrome Sobin et al., 2006 62 UPSIT
Agnosia Kopala and Clark, 1990 77 UPSIT
Alcoholism Rupp et al., 2004 60 Sniffin’ Sticks
Alzheimer’s disease Waldton, 1974 100 Odor identification test
Amyotrophic lateral sclerosis Viguera et al., 2018 147 UPSIT
Anesthesia cognitive impairment Zhang et al., 2022 242 Sniffin’ Sticks
Anorexia Roessner et al., 2005 32 Sniffin’ Sticks
Anxiety Chen X. et al., 2021 107 Sniffin’ Sticks
Autism Kinnaird et al., 2020 80 Sniffin’ Sticks
Autoimmune encephalitis Geran et al., 2019 64 Sniffin’ Sticks
Bardet-Biedl syndrome Iannaccone et al., 2005 15 UPSIT
Bipolar disorder Kazour et al., 2020 176 Odor identification, odor discrimination
Blepharospasm Gamain et al., 2021 34 Sniffin’ Sticks
Cerebral palsy Nakashima et al., 2019 14 Japanese odor stick identification test
Chagas’ disease Leon-Sarmiento et al., 2014 120 UPSIT
Childhood maltreatment Croy et al., 2010 22 Sniffin’ Sticks
Cluster headache Samancı et al., 2021 57 Sniffin’ Sticks
Corticobasal syndrome Luzzi et al., 2007 7 Odour Perception and Semantics Battery
COVID-19 Vaira et al., 2020 150 CCCRC olfaction test
Creutzfeldt-Jakob disease Reuber et al., 2001 1 Unnamed test
Cystic fibrosis Di Lullo et al., 2020 121 Sniffin’ Sticks
Depression (unipolar) Eliyan et al., 2021 3546 Sniffin’ Sticks
Down syndrome Cecchini et al., 2016 56 Sniffin’ Sticks
Dystonia Marek et al., 2018 198 Sniffin’ Sticks
Epilepsy Khurshid et al., 2019 912 UPSIT, Sniffin’ Sticks, other tests
Essential tremor Elhassanien et al., 2021 46 Sniffin’ Sticks
Fibromyalgia Amital et al., 2014 45 Sniffin’ Sticks
Fragile X syndrome Juncos et al., 2012 83 UPSIT
Friedreich ataxia Connelly et al., 2002 35 UPSIT
Frontotemporal dementia Luzzi et al., 2007 11 Odour perception and semantics battery
Gaucher disease McNeill et al., 2012 60 UPSIT
HIV/AIDS Zucco and Ingegneri, 2004 48 UPSIT
Huntington’s disease Fernandez-Ruiz et al., 2003 162 UPSIT
Idiopathic intracranial hypertension Bershad et al., 2014 38 UPSIT, Sniffin’ Sticks, other tests
Inflammation Schubert et al., 2015 1611 San Diego odor identification test
Kallmann syndrome Gregson and Smith, 1981 26 Campbell Gregson procedure
Lewy body dementia Yoo et al., 2018 217 Cross-cultural smell identification test
Memory loss with aging Doty et al., 1984 1995 UPSIT
Migraine headaches Whiting et al., 2015 100 UPSIT
Mild cognitive impairment Peters et al., 2003 100 Sniffin’ Sticks
Multiple sclerosis Atalar et al., 2018 55 CCCRC olfactory test
Multiple-system atrophy Abele et al., 2003 8 Sniffin’ Sticks
Myasthenia gravis Leon-Sarmiento et al., 2012 27 Spanish UPSIT
Myotonic dystrophy Masaoka et al., 2011 7 T&T olfactometer
Narcolepsy Buskova et al., 2010 66 UPSIT
Niemann-Pick Mishra et al., 2016 2 Not indicated
OCD Berlin et al., 2017 30 UPSIT, hedonics and intensity
Parkinson’s disease Haehner et al., 2009 50 Sniffin’ Sticks
Long covid Burges Watson et al., 2021 9000 Self-report
Posterior cortical atrophy Witoonpanich et al., 2013 15 UPSIT
Posttraumatic stress disorder Vasterling et al., 2000 68 UPSIT
Prenatal alcohol syndrome Bower et al., 2013 16 San Diego odor identification test
Progressive supranuclear palsy Shill et al., 2021 281 UPSIT
Pure autonomic failure Goldstein and Sewell, 2009 51 UPSIT
REM sleep behavior disorder Iranzo et al., 2021 140 UPSIT
Repetitive head impacts Alosco et al., 2017 123 Brief smell identification test
Schizophrenia Kopala et al., 1993 98 UPSIT
Semantic dementia Luzzi et al., 2007 20 Odor naming
Spinocerebellar ataxias Abele et al., 2003 24 Sniffin’ Sticks
Stroke Wehling et al., 2015 78 Sniffin’ Sticks
Systemic lupus erythematosus Schoenfeld et al., 2009 100 Sniffin’ Sticks
Systemic sclerosis Amital et al., 2014 65 Sniffin’ Sticks
Tourette syndrome Kronenbuerger et al., 2018 56 Sniffin’ Sticks
Traumatic brain injury Frasnelli et al., 2016 63 Sniffin’ Sticks
Usher syndrome Ribeiro et al., 2016 130 Sniffin’ Sticks
Vascular dementia Suh et al., 2020 1 Korean Sniffin’ Sticks
Wilson’s disease Chen L. et al., 2021 50 UPSIT
Zika/Guillain-Barré syndrome Lazarini et al., 2022 38 Sniffin’ Sticks