Fig. 2.

Phylogenetic tree revealing the evolutionary history of Schistosoma mansoni HSPs. The evolutionary history of the HSP 10, 40, 60, 70 and 90 families was inferred by neighbour-joining method analysis [74]. Evolutionary distances were computed using the Poisson correction method [75]. The analysis involved 54 amino acid sequences (one each of HSP 10 and 60, eleven of HSP 70, three of HSP 90 and 38 of HSP 40); one HSP 70 member was excluded as it contained significant gaps in the alignment. The analysis (unrooted circular tree) was conducted using Molecular Evolutionary Genetic Analysis (MEGA) X [76]