Table 5.

Interocular Symmetry of Capillary Perfusion Density and Capillary Flux Index

Diagnosis	Alzheimer Disease		Mild Cognitive Impairment		Parkinson Disease		Normal Cognition
N (eye pairs)	11		30		34		60
	Mean Δ∗ (SD, %Δ)	P†	Mean Δ∗ (SD, %Δ)	P†	Mean Δ∗ (SD, %Δ)	P†	Mean Δ∗ (SD, %Δ)	P†
Capillary Perfusion Density
Average	0.47 (2.17, 4.09%)	0.206	0.13 (0.97, 0.33%)	0.725	0.20 (1.70, 0.57%)	0.927	0.14 (1.17, 0.31%)	0.222
Superior	0.27 (1.72, 1.32%)	0.765	0.39 (2.07, 0.91%)	0.307	0.20 (3.61, 0.27%)	0.055	0.22 (2.17, 0.55%)	0.575
Nasal	1.33 (1.96, 3.14%	0.049	0.53 (2.29, 1.29%)	0.260	0.77 (2.09, 1.94%)	0.036	0.71 (2.20, 1.70%)	0.016
Inferior	1.15 (2.57, 2.77%)	0.102	0.30 (2.54, 0.69%)	0.312	0.54 (2.09, 1.35%)	0.227	0.21 (1.83, 0.46%)	0.205
Temporal	1.79 (2.17, 4.09%)	0.024	0.57 (2.01, 1.26%)	0.130	0.31 (2.26, 0.65%)	0.329	0.22 (1.94, 0.50%)	0.536
Capillary Flux Index
Average	0.007 (0.018, 1.80%)	0.413	0.008 (0.023, 2.06%)	0.107	0.006 (0.022, 1.42%)	0.226	0.005 (0.021, 1.12%)	0.035
Superior	0.008 (0.018, 2.07%)	0.249	0.009 (0.020, 2.25%)	0.028	0.004 (0.023, 1.16%)	0.580	0.004 (0.022, 0.85%)	0.061
Nasal	0.010 (0.018, 2.49%)	0.086	0.007 (0.024, 1.81%)	0.130	0.005 (0.028, 1.36%)	0.598	0.005 (0.026, 1.26%)	0.218
Inferior	0.008 (0.020, 2.15%)	0.288	0.004 (0.024, 1.04%)	0.450	0.004 (0.020, 1.05%)	0.481	0.003 (0.019, 0.85%)	0.149
Temporal	0.003 (0.018, 1.80%)	0.770	0.012 (0.033, 3.07%)	0.040	0.010 (0.030, 2.29%)	0.054	0.006 (0.029, 1.48%)	0.035

SD = standard deviation. Boldface indicates statistical significance.

^∗Mean difference calculated by subtracting maximum of the mean parameter value (right or left eye) from the minimum value (corresponding left or right eye), with the corresponding percent difference calculated as this difference divided by the minimum mean parameter value.

^†P value calculated using the Wilcoxon signed-rank test using the mean difference between eyes.