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Determination of the best solvent for the generation of 7a.
| Entry | Solvent | Time (h) | Yield % a |
|---|---|---|---|
| 1 | EtOH | 15 | None |
| 2 | CH2Cl2 | 8 | 60 |
| 3 | CHCl3 | 5 | 68 |
| 4 | H 2 O | 3 | 95 |
| 5 | Solvent free | 8 | 58 |
| 6 | DMF | 12 | 30 |
| 7 | Toluene | 12 | 68 |
| 8 | CH3CN | 5 | 90 |
Isolated yields.
Bold indicates best condition for performing reactions.
