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. 2022 Sep 29;9:986542. doi: 10.3389/fnut.2022.986542

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Copyright © 2022 Savary-Auzeloux, Jarzaguet, Migné, Kemeny, Novais-Gameiro, de Azevedo, Mathé, Mariotti, Langella, Chatel and Dardevet.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impact of Dextran sodium sulfate with (PB1) or without probiotic supplementation (DSS) on colon and muscle physiology/protein metabolism in adult older rats. (A) Evolution of rats weight (g), lean mass (g) and fat mass (g), (B) Evolution of hindlimb and colon masses (g), (C) Evolution of colon and gastrocnemius absolute synthesis rats (mg protein/ day), (D) Evolution of mRNA levels of muscle proteins involved in autophagy and Ubiquitin-proteasome pathways or regulation of these pathways. Values are means ± SEM different letters indicate significant differences between groups (P < 0.05) and were obtained by one way Anova or Wilkoxon rank sum test. Number of samples are 14, 14, 12 in PF, DSS and PB1 groups.