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. Author manuscript; available in PMC: 2023 Oct 10.
Published in final edited form as: Cancer Cell. 2022 Sep 29;40(10):1161–1172.e5. doi: 10.1016/j.ccell.2022.08.022

Figure 1: See also Figures S1-S4 and Tables S1-S2 TMB overestimation in tumor-only sequencing panels driven by false positive germline variants in non-Europeans.

Figure 1:

A. Annotating somatic and germline variants across self-reported race and effect on TMB calculations. The orange color in the DNA molecule refers to the European component of the genome and the navy-blue color refers to the African component. B. Germline reference panels where non-Europeans are underrepresented. This is driven by genetic ancestry and not by race as an individual with high non-European ancestry will have the same bias in their tumor-only TMB estimate whether they self-report as white or non-white. See also Figures S1-S4 and Tables S1 and S2.