Table 1. Studies included in the systematic review.

Author	Year Published	Animal Model or Cell Line Details			Poguntano Extract				Outcome
		Animal Model/Cell Line	Sample size	Intervention period	Sample Used	Extraction method	Dose	Administration Method	Glucose index outcome	Endothelin-1 Outcome
Widjaja	2018	Male wistar rats	15	4 weeks	Picria fel-terrae Lour. leaves	Maceration technique with ethanol 96% (Ethanol extract)	200 mg/kg	Oral	Plasma glucose reduction of 302 mg/dL on the poguntano group, as compared to 62 mg/dL in diabetic control and 386 mg/dL in insulin group.	Endothelin-1 showed statistical significant between group with normal rats and diabetic control rats. (p=0.009) but did not showed significant results in the other groups. Levels of Endothelin-1 were higher in the diabetic control group with the median 1.95 (1.78-3.1) than the other groups.
Sumantri I	2018	Wistar rats, weight of 25-30 g	10	2 hours	Picria fel-terrae Lour. leaves	Percolation extraction with ethanol 96% as solvent (Ethanol extract); suspended with CMC-Na 1% concentrate	Crude extract of poguntano: 50,100, 200 mg/kg	Oral	Plasma glucose reduction of 12.58;46.59;17.41 mg/dL respectively for 50,100, and 200 mg/kgBW of poguntano crude extract; as compared to 12.33 mg/dL plasma glucose reduction on glibenclamide group	N/A
Widjaja S	2017	Male wistar rats, weighing 150-250 g	15	4 weeks	Picria fel-terrae Lour. leaves	Maceration technique with ethanol 96% (Ethanol extract)	200 mg/kg and 300 mg/kg	Oral	Plasma glucose reduction of 373 mg/dL and 302 mg/dL respectively for 300 mg/kg and 200 mg/kg dose; as compared to 62 mg/dL on the diabetic control and 386 mg/dL on the insulin group	N/A