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The nuclear receptor superfamily is classified into eight families based on sequence conservation of the C (DBD) and E (LBD) domains.
| S. No. | Family abbreviation | Family Name |
|---|---|---|
| 1. | NR1 | Thyroid Hormone Receptor-like |
| 2. | NR2 | Retinoid X Receptor-like |
| 3. | NR3 | Estrogen Receptor-like |
| 4. | NR4 | Nerve Growth Factor IB-like |
| 5. | NR5 | Steroidogenic Factor-like |
| 6. | NR6 | Germ Cell Nuclear Factor-like |
| 7. | NR7 | NRs with two DNA binding domains |
| 8. | NR0 | NRs lack either LBD or DBD |
