Table 1.
Baseline characteristics of the cohort
| Variable | NSCLC cases (n = 241) | Cancer-free controls (n = 234) | p-value |
|---|---|---|---|
| Age | |||
| Mean (range) | 69 (49–88) | 55 (20–89) | p < 0.001 |
| Sex | |||
| Male (%) | 112 (46%) | 69 (29%) | p < 0.001 |
| Female (%) | 129 (54%) | 165 (71%) | |
| Stage (AJCC 7th ed.) | |||
| I (%) | 145 (60%) | N/A | - |
| II (%) | 50 (21%) | ||
| III (%) | 41 (17%) | ||
| IV (%) | 5 (2%) | ||
| NSCLC type | |||
| Adenocarcinoma (%) | 177 (73%) | N/A | - |
| Squamous cell carcinoma (%) | 64 (27%) | ||
| Body mass index | |||
| Mean (range) | 27.2 (14.8–49.5) | 27.0 (16.4–49.6) | 0.7 |
| Comorbidities | |||
| Diabetes (%) | 55 (23%) | 16 (7%) | < 0.001 |
| COPD (%) | 68 (28%) | 17 (7.3%) | < 0.0001 |
| Hypertension (%) | 129 (54%) | 44 (19%) | < 0.001 |
| Dyslipidemia (%) | 91 (38%) | 35 (15%) | < 0.001 |
| Cardiovascular disease (%) | 72 (30%) | 14 (6%) | < 0.001 |
| Smoking history | |||
| Current smoker (%) | 65 (27%) | 15 (6%) | < 0.001 |
| Ex-smoker (%) | 156 (65%) | 51 (22%) | |
| Never smoker (%) | 20 (8%) | 48 (21%) | |
| Unknown (%) | 0 | 120 (51%) | |