. 2021 Mar 6;1(1):100005. doi: 10.1016/j.xops.2021.100005

Table 3.

Linear Mixed Modeling for Predictors of Expansion Rates in Definitely Decreased Autofluorescence Area and Square Root Area

Predictor	Category	Data^∗	Definitely Decreased Autofluorescence Area Expansion Rate (mm²/yr)			Definitely Decreased Autofluorescence Square Root Area Expansion Rate (mm/yr)
Predictor	Category	Data^∗	Model Estimate ± SE	F(v₁, v₂)^†	P Value	Model Estimate ± SE	F(v₁, v₂)^†	P Value
Gender	Female	24 (49)	–0.188 ± 0.341	F(1, 41.5) = 0.304	0.584	–0.042 ± 0.038	F(1, 43.1) = 1.225	0.274
Gender	Male	25 (51)	1.00 (reference)^‡	F(1, 41.5) = 0.304	0.584	1.00 (reference)^‡	F(1, 43.1) = 1.225	0.274
Eye	Left	49 (50)	0.046 ± 0.205	F(1, 47.6) = 0.050	0.824	0.001 ± 0.016	F(1, 47.6) = 0.006	0.939
Eye	Right	49 (50)	1.00 (reference)^‡	F(1, 47.6) = 0.050	0.824	1.00 (reference)^‡	F(1, 47.6) = 0.006	0.939
Genotype group	A	14 (28.6)	0.25 ± 0.67	F(2, 42.7) = 1.549	0.224	0.169 ± 0.074	F(2, 46.2) = 3.298	0.046
	B	20 (40.8)	0.757 ± 0.502			0.137 ± 0.056		0.046
	C	15 (30.6)	1.00 (reference)^‡			1.00 (reference)^‡
Age at baseline assessment (yrs)		41.3 ± 20.2	0.004 ± 0.023	F(1, 47.4) = 0.025	0.876	0.007 ± 0.003	F(1, 67.8) = 7.477	0.008
Age at symptom onset (yrs)		26 ± 23.2	0.008 ± 0.021	F(1, 49.6) = 0.129	0.721	–0.004 ± 0.002	F(1, 63.6) = 2.466	0.121
Baseline visual acuity		39.9 ± 29.9	–0.012 ± 0.009	F(1, 77) = 1.807	0.183	–0.0005 ± 0.001	F(1, 88.3) = 0.293	0.590
Baseline DDAF area/SRA^§		16.4 ± 28.3	0.044 ± 0.01	F(1, 52.4) = 20.516	< 0.001	–0.026 ± 0.011	F(1, 87.1) = 5.640	0.020

DDAF = definitely decreased autofluorescence; SE = standard error; SRA = square root area.

^∗

Presented as no. (%) or mean ± standard deviation for continuous variables.

^†

Observed F statistic with v₁ and v₂ degrees of freedom.

^‡

The reference level in the categorical predictor is defined as 1.00 (reference).

^§

Definitely decreased autofluorescence area was used as the predictor for area expansion rate, whereas DDAF SRA was the predictor for SRA expansion rate.