Table 3.
Association of the GC-IPL and RNFL Thickness with the Regional Brain Volume/ICV, Estimated by the FreeSurfer Software, 2017
| GC-IPL Thickness per Every 1 SD Decrement |
RNFL Thickness per Every 1 SD Decrement |
|||||||
|---|---|---|---|---|---|---|---|---|
| β | 95% CI | P Value | q Value of FDR Correction | β | 95% CI | P Value | q Value of FDR Correction | |
| Total Study Population (n = 1078) | ||||||||
| Hippocampus | −0.0040 | (−0.0072 to −0.0009) | 0.01 | 0.02 | −0.0025 | (−0.0057 to 0.0006) | 0.12 | 0.31 |
| Amygdala | −0.0019 | (−0.0032 to −0.0005) | 0.01 | 0.02 | −0.0009 | (−0.0023 to 0.0006) | 0.24 | 0.32 |
| Entorhinal cortex | −0.0011 | (−0.0039 to 0.0017) | 0.46 | 0.46 | 0.0001 | (−0.0027 to 0.0029) | 0.94 | 0.94 |
| Parahippocampal gyrus | −0.0008 | (−0.0029 to 0.0013) | 0.45 | 0.51 | 0.0007 | (−0.0014 to 0.0028) | 0.53 | 0.60 |
| Cuneus | −0.0047 | (−0.0078 to −0.0016) | 0.003 | 0.03 | −0.0051 | (−0.0082 to –0.0020) | 0.002 | 0.01 |
| Lingual gyrus | −0.0066 | (−0.0126 to −0.0007) | 0.03 | 0.045 | −0.0046 | (−0.0106 to 0.0014) | 0.14 | 0.27 |
| Thalamus | −0.0054 | (−0.0092 to −0.0015) | 0.01 | 0.03 | −0.0052 | (−0.0091 to −0.0012) | 0.01 | 0.04 |
| White matter hyperintensities | 0.0388 | (−0.0091 to 0.0787) | 0.10 | 0.10 | 0.0269 | (−0.0134 to 0.0672) | 0.19 | 0.30 |
CI = confidence interval; FDR = false discovery rate; GC-IPL = ganglion cell-inner plexiform layer; ICV = intracranial volume; RNFL = retinal nerve fiber layer; SD = standard deviation.
Regional brain volume is calculated as a percentage of ICV as follows: (regional brain volume/ICV) x 100 (%).
The FDR correction was performed to verify the multiple comparisons for which a significance level with a q value of FDR correction was defined as <0.10.
The values were adjusted for age, sex, education, systolic blood pressure, use of antihypertensive agents, diabetes, serum total cholesterol, body mass index, cerebrovascular lesions on magnetic resonance imaging, smoking habits, drinking habits, regular exercise, and axial length.