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. 2022 Oct 11;99(15):e1640–e1650. doi: 10.1212/WNL.0000000000200953

Figure 3. Hazard Ratios for the Baseline CSF Measures at Specific Baseline Ages, Stratified by Sex.

Figure 3

In male participants (blue line), compared with female participants (red line), higher CSF ptau (ptau181) levels (A) and lower ratios of CSF Aβ42/Aβ40 (B) are associated with a shorter time to symptom onset, with the difference between the sexes diminishing as baseline age increases. For illustration purposes, hazard ratios were calculated from the Cox regression models at specific age points (age 50, 60, and 70 years) stratified by sex, using the Cox regression models with the 3-way interactions (CSF measures × age × sex, years of education, and ApoE4 carrier status). ApoE = Apolipoprotein E.