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. 2022 Aug 11;133(4):867–875. doi: 10.1152/japplphysiol.00837.2021

Figure 3.

Figure 3.

Physiological response to acute intermittent hypoxia and impact of bosentan. Data are from n = 12 men unless noted (baroreflex sensitivity and T50, n = 9). Two-way repeated-measures ANOVA testing the main effect of IH (pre, post) and drug (control, bosentan) and the interaction of IH and drug (normality: Shapiro–Wilk, equal variance: Brown–Forsythe). Pairwise multiple comparison (Holm–Sidak). *P < 0.05 main effect of IH. †P < 0.05 main effect of drug. IH, intermittent hypoxia. A: plasma endothelin-1. B: mean blood pressure. C: cardiac output. D: total peripheral resistance. E: MSNA burst frequency. F: arterial baroreflex sensitivity. G: T50.