Table 1.

Effect of acute intermittent hypoxia on blood pressure regulation and impact of bosentan

	Control		Bosentan		P Values
	Pre IH	Post IH	Pre IH	Post IH	IH	Drug	Interaction
Systolic blood pressure, mmHg	139 ± 3	143 ± 2	137 ± 3	138 ± 3	0.16	0.35	0.18
Diastolic blood pressure, mmHg	73 ± 1	76 ± 2	68 ± 1	69 ± 2	<0.01	<0.01	0.13
Mean blood pressure, mmHg	94 ± 2	98 ± 2	88 ± 2	90 ± 2	<0.01	<0.01	0.12
Heart rate, beats/min	57 ± 2	59 ± 3	58 ± 2	60 ± 2	0.19	0.66	0.39
Stroke volume, mL/beat	103 ± 4	103 ± 4	107 ± 4	106 ± 4	0.92	0.30	0.76
Cardiac output, L/min	5.6 ± 0.4	5.7 ± 0.5	5.8 ± 0.3	6.0 ± 0.3	0.20	0.27	0.45
Total peripheral resistance, mmHg·s/mL	1.02 ± 0.05	1.04 ± 0.07	0.90 ± 0.04	0.90 ± 0.04	0.73	0.02	0.66

Data are reported as means ± SE from n = 12 men. Two-way repeated-measures ANOVA testing the main effect of IH (pre, post) and drug (control, bosentan) and the interaction of IH and drug (normality: Shapiro–Wilk, equal variance: Brown–Forsythe). Pairwise multiple comparison (Holm–Sidak). IH, intermittent hypoxia. Bold type signifies P < 0.05.