Table 2. MARV therapeutics with protective efficacy in the NHP model.

Treatment	Challenge virus	Treatment postchallenge	Treatment dose	Number of doses	Survival [%]	Ref.
VSV-MARV	MARV Musoke	20–30 minutes	1 × 107 PFU	1	100	[40]
	MARV Musoke	1 day	2 × 107 PFU	1	83	[40]
	MARV Musoke	2 days	2 × 107 PFU	1	33	[40]
	MARV Angola	20–30 minutes	1 × 103 PFU	1	25	[41]
	MARV Angola	20–30 minutes	50 PFU	1	89	[42]
VSVN2CT1-MARV	MARV Angola	20–30 minutes	50 PFU	1	80	[42]
VSVN4CT1-MARV	MARV Angola	20–30 minutes	50 PFU	1	60	[41]
MR191-N	MARV Angola	4 days	50 mg/kg	2	100	[40]
	MARV Angola	5 days	50 mg/kg	2	80	[40]
	RAVV	5 days	50 mg/kg	2	100	[40]
MR186-YTE	MARV Angola	5 days	100 mg/kg	1	100	[43]
		6 days	100 mg/kg	1	0	[43]
MR186-YTE + Remdesivir	MARV Angola	6 days	100 mg/kg	1	80	[43]
	MARV Angola	6 days	10 mg/kg load. 5 mg/kg maint.	12	80	[43]
Remdesivir	MARV Angola	5 days	10 mg/kg load. 5mg/kg maint.	12	80	[43]
	MARV Angola	6 days	10 mg/kg load. 5 mg/kg maint.	12	0	[43]
	MARV Angola	4 or 5 days	10 mg/kg load. 5 mg/kg maint.	12	85	[44]
	MARV Angola	5 days	5 mg/kg load. 5 mg/kg maint.	12	50	[44]
BCX4430	MARV Musoke	1 hour	15 mg/kg	30	83	[40]
	MARV Musoke	1 day	15 mg/kg	28	100	[40]
	MARV Musoke	2 days	15 mg/kg	26	100	[40]
siRNA (NP)	MARV Angola	1, 2, 3, or 4 days	0.5 mg/kg	7	100	[40]
	MARV Angola	5 days	0.5 mg/kg	7	50	[40]
	RAVV	3 or 6 days	0.5 mg/kg	7	100	[40]
PMOplus (pool)	MARV Musoke	30–60 minutes	40 mg/kg	14	100	[40]
PMOplus (NP)	MARV Musoke	1 hour	15 mg/kg	14	83	[40]
	MARV Musoke	1 or 4 days	15 mg/kg	14	83	[40]
	MARV Musoke	2 days	15 mg/kg	14	100	[40]
rNAPc2	MARV Angola	10 minutes	30 μg/kg	15	17	[40]
IFNβ	MARV Musoke	1 hour	35 μg/kg	15	33	[40]
Favipiravir	MARV Angola	at challenge	250 mg/kg load. 150 mg/kg maint.	3	85	[45]

load., loading dose; maint., maintenance dose.