Key resources table.

Reagent type (species) or resource	Designation	Source or reference	Identifiers	Additional information
Antibody	Mouse anti-p53 (DO-1, mouse monoclonal)	Invitrogen	AHO0152	1 µg/mL
Antibody	Horseradish peroxidase conjugated goat anti-mouse antibody (goat polyclonal)	Abcam	Ab205719	1:25,000
Chemical compound, drug	N-methyl-N′-nitroso-N-nitrosoguanidine	Sigma-Aldrich	129941
Cell line (human)	A549-luc-C8	Xenogen Corporation	N/A
Sequence- based reagent	p53 siRNA I	Cell Signaling Technology	6231
Sequence- based reagent	Control siRNA	Cell Signaling Technology	6568
Software, algorithm	MetaMorph (Quorum WaveFX, v7.8.12.0)	Quorum Technology	N/A
Software, algorithm	ImageJ	Schneider et al., 2012	https://imagej.nih.ggov/ij/
Software, algorithm	Computerized single-cell lineage tracking analysis system software	Rancourt, Sato, and Satoh	BioRxiv. doi: https://doi.org/10.1101/508705
Software, algorithm	Cell fate simulation algorithm	This paper		Results: ‘Cell-fate simulation algorithm’; Materials and methods: ‘Overall flow of cell-fate simulation algorithm’; Figure 7—source code 1
Other	Cell lineage data	This paper		Deposited in Dryad