Table 4.
Neutrophil, Monocyte, and Lymphocyte Fractions, Neutrophil-to-Lymphocyte Ratio, and Lymphocyte-to-Monocyte Ratio in Relationship to Clinical and Histopathologic Findings in the Total Cohort of 183 Patients and in the 82 Patients Who Underwent Enucleation for Uveal Melanoma Analyzed with an Independent-Samples t Test
| Clinical and Pathologic Findings | Neutrophils (%) |
Monocytes (%) |
Lymphocytes (%) |
Neutrophil-to-Lymphocyte Ratio |
Lymphocyte-to-Monocyte Ratio |
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| Mean ± Standard Deviation | P Value | Mean ± Standard Deviation | P Value | Mean ± Standard Deviation | P Value | Mean ± Standard Deviation | P Value | Mean ± Standard Deviation | P Value | |
| All patients | ||||||||||
| Primary tumor location | ||||||||||
| Choroid (n = 151) | 65.2 ± 7.9 | 0.95 | 7.9 ± 2.2 | 0.23 | 24.3 ± 6.7 | 0.74 | 3.0 ± 1.3 | 0.59 | 3.3 ± 1.4 | 0.21 |
| Ciliary body (n = 20) | 65.3 ± 10.0 | 7.3 ± 2.4 | 24.9 ± 8.6 | 3.2 ± 1.8 | 3.7 ± 1.5 | |||||
| AJCC T classification | ||||||||||
| T1 (n = 26) | 63.6 ± 9.6 | 0.76 | 7.8 ± 2.4 | 0.90 | 25.6 ± 8.5 | 0.79 | 2.9 ± 1.6 | 0.96 | 3.5 ± 1.5 | 0.72 |
| T2 (n = 49) | 65.6 ± 8.1 | 7.7 ± 2.5 | 24.3 ± 6.4 | 3.0 ± 1.3 | 3.4 ± 1.5 | |||||
| T3 (n = 73) | 64.5 ± 8.1 | 7.8 ± 2.2 | 24.0 ± 6.9 | 3.1 ± 1.3 | 3.3 ± 1.4 | |||||
| T4 (n = 21) | 65.1 ± 7.1 | 8.1 ± 1.4 | 24.4 ± 6.7 | 3.0 ± 1.2 | 3.1 ± 1.1 | |||||
| Patients who underwent enucleation | ||||||||||
| Ciliary body involvement | ||||||||||
| No (n = 52) | 64.7 ± 9.2 | 0.11 | 7.8 ± 2.2 | 0.12 | 24.9 ± 7.3 | 0.26 | 3.0 ± 1.4 | 0.30 | 3.4 ± 1.2 | 0.38 |
| Yes (n = 28) | 68.1 ± 8.6 | 7.0 ± 2.3 | 23.0 ± 7.6 | 3.4 ± 1.6 | 3.7 ± 1.6 | |||||
| Presence of epithelioid cells | ||||||||||
| No (n = 25) | 65.9 ± 7.7 | 0.84 | 7.4 ± 1.7 | 0.90 | 24.4 ± 6.3 | 0.89 | 3.0 ± 1.3 | 0.75 | 3.4 ± 1.1 | 0.66 |
| Yes (n = 56) | 65.4 ± 9.7 | 7.5 ± 2.4 | 24.6 ± 8.0 | 3.1 ± 1.6 | 3.6 ± 1.5 | |||||
| Necrosis | ||||||||||
| No (n = 47) | 64.5 ± 9.5 | 0.17 | 7.5 ± 2.3 | 0.69 | 25.6 ± 7.6 | 0.052 | 2.9 ± 1.4 | 0.12 | 3.6 ± 1.2 | 0.07 |
| Yes (n = 16) | 68.1 ± 7.1 | 7.8 ± 2.1 | 21.4 ± 6.4 | 3.5 ± 1.4 | 3.0 ± 1.4 | |||||
| Extraocular extension | ||||||||||
| No (n = 54) | 4.7 ± 8.8 | 0.22 | 7.4 ± 2.2 | 0.29 | 25.3 ± 7.3 | 0.13 | 2.9 ± 1.3 | 0.11 | 3.7 ± 1.5 | 0.09 |
| Yes (n = 13) | 68.1 ± 8.4 | 8.2 ± 2.7 | 21.8 ± 7.3 | 3.6 ± 1.7 | 2.9 ± 1.3 | |||||
| BAP1 staining | ||||||||||
| Positive (n = 28) | 64.8 ± 8.2 | 0.72 | 7.1 ± 1.9 | 0.17 | 25.2 ± 6.7 | 0.53 | 2.9 ± 1.6 | 0.31 | 3.7 ± 1.3 | 0.09 |
| Negative (n = 40) | 65.8 ± 9.9 | 7.9 ± 2.3 | 24.0 ± 8.1 | 3.2 ± 1.6 | 3.2 ± 1.2 | |||||
AJCC = American Joint Committee on Cancer.