Table 1.
Characteristics of the Reduced-fluence Photodynamic Therapy Group and Control Group
| Unweighted |
IPTW Adjusted |
|||||
|---|---|---|---|---|---|---|
| rf-PDT (n = 74) | Control (n = 81) | P Value | rf-PDT | Control | Standardized Difference | |
| Male∗ | 56 (75.7) | 59 (72.8) | 0.83 | (78.0) | (74.8) | –0.032 |
| Age (yrs)∗ | 60.1 ± 10.9 | 55.1 ± 11.5 | 0.006 | 57.3 ± 10.4 | 56.4 ± 11.1 | 0.083 |
| Smoking status∗ | ||||||
| Current | 17 (23.0) | 17 (21.0) | 0.72 | (18.9) | (20.6) | –0.017 |
| Former | 22 (29.7) | 29 (35.8) | (37.0) | (34.4) | 0.026 | |
| Never | 35 (47.3) | 35 (43.2) | (44.1) | (44.9) | –0.009 | |
| Brinkman index∗ | 323 ± 461 | 274 ± 380 | 0.46 | 310 ± 402 | 288 ± 412 | 0.050 |
| Steroid intake∗ | 5 (6.8) | 3 (3.7) | 0.62 | (3.8) | (2.9) | 0.009 |
| Phakic eyes∗ | 70 (94.6) | 76 (93.8) | 1.0 | (96.0) | (95.3) | 0.007 |
| No. of previous episodes∗ | 0.53 ± 0.87 | 0.36 ± 1.25 | 0.33 | 0.40 ± 0.80 | 0.39 ± 1.38 | 0.020 |
| Symptom duration of the current episode (mo)∗ | 13.0 ± 31.3 | 8.5 ± 32.5 | 0.40 | 9.95 ± 23.0 | 9.39 ± 37.4 | 0.017 |
| Initial BCVA (logMAR)∗ | 0.16 ± 0.27 | 0.01 ± 0.17 | <0.001 | 0.08 ± 0.23 | 0.06 ± 0.22 | 0.051 |
| FA findings | ||||||
| Diffuse leakage∗ | 70 (94.6) | 67 (87.0) | 0.19 | (88.9) | (89.1) | 0.020 |
| Number of focal leakages∗ | 0.89 ± 0.84 | 0.69 ± 0.80 | 0.13 | 0.77 ± 0.76 | 0.72 ± 0.87 | 0.060 |
| ICGA findings | ||||||
| CVH in affected eye∗ | 40 (54.8) | 42 (52.5) | 0.90 | (55.0) | (54.9) | 0.001 |
| CVH in fellow eye∗ | 33 (45.2) | 37 (46.2) | 1.0 | (48.0) | (49.3) | –0.012 |
| OCT findings | ||||||
| Foveal neurosensory retinal thickness (μm)∗ | 129 ± 31 | 145 ± 37 | 0.003 | 141 ± 39 | 138 ± 36 | 0.090 |
| Height of SRD (μm)∗ | 184 ± 104 | 163 ± 113 | 0.22 | 163 ± 103 | 165 ± 112 | –0.014 |
| Cystoid macular edema∗ | 0 (0.0) | 4 (4.9) | 0.15 | (0.0) | (2.9) | –0.029 |
| Pigment epithelium detachment∗ | 9 (12.2) | 10 (12.3) | 1.0 | (8.9) | (8.3) | 0.006 |
| RPE alteration grading∗ | ||||||
| <1 optic disc area | 41 (55.4) | 52 (67.5) | 0.27 | (58.5) | (63.2) | –0.046 |
| 1−5 optic disc area | 26 (35.1) | 21 (27.3) | (35.6) | (32.1) | 0.035 | |
| > 5 optic disc area | 7 (9.5) | 4 (5.2) | (5.9) | (4.8) | 0.012 | |
Presented by mean ± standard deviation or count (%).
BCVA = best-corrected visual acuity; CVH = choroidal vascular hyperpermeability; FA = fluorescein angiography; ICGA = indocyanine green angiography; IPTW = inverse probability of treatment weighting; logMAR = logarithm of the minimum angle of resolution; rf-PDT = reduced-fluence photodynamic therapy; RPE = retinal pigment epithelium; SRD = serous retinal detachment.
∗
Eighteen characteristics used for creating the IPTW model.