Figure.

BA.2.75.2 escapes neutralising antibodies

(A) Differences from BA.2 in BA.2.75 (orange), and BA.2.75.2 (red, underlined), depicted upon the SARS-CoV-2 BA.2 receptor binding domain (pdb:7UB0). Sensitivity of SARS-CoV-2 omicron sublineages and ancestral B.1 (D614G) to neutralisation by monoclonal antibodies (B), and randomly sampled sera from blood donated in Stockholm, Sweden, between Nov 8–14, 2021 (n=25; C), April 11–17, 2022 (n=25; D), and Aug 29 to Sept 4, 2022 (n=25; E). Sera with neutralisation less than 50% at the lowest dilution tested (20) are plotted as 20 (dotted line). IC₅₀=50% inhibitory concentration. ID₅₀=50% inhibitory dilution. *Indicates reversion.