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Methylation and demethylation of natural products under the action of gut microbes. (A) Methylation of rutin (Wu et al., 2017); (B–F) Demethylation of aconitine (Zhang et al., 2017), arctigenin (Jin et al., 2013), 5,7,4-trimethoxyflavone (Kim et al., 2014), 22β-acetoxyl glycyrrhizin (Wang Q. et al., 2015), isoxanthohumol (Paraiso et al., 2019).
